Vaccine Suiseng Coli/C

Each dose (2 ml) contains:  
Active substances:  
- E. coli F4ab fimbrial adhesin: ≥ 65% ER₆₀ *  
- E. coli F4ac fimbrial adhesin: ≥ 78% ER₁₀  
- E. coli F5 fimbrial adhesin: ≥ 79% ER₅₀  
- E. coli F6 fimbrial adhesin: ≥ 80% ER₂₅  
- E. coli thermolabile enterotoxin: ≥ 55% ER₁₀  
- Attenuated Clostridium perfringens type C toxin: RP > 1.05 **  
- Attenuated Clostridium novyi type B toxin: RP > 1.23 **  
*% ERₓ: percentage of immunized rabbits with a serological response X in the EIA test  
**RP: Relative potency determined by ELISA  

Adjuvants:  
- Aluminum hydroxide gel: 0.5 g (5.3 mg Al)  
- Ginseng extract (equivalent to ginsenosides): 4 mg (0.8 mg)  

Excipient:  
Qualitative composition of excipients and other constituents:  
- Simethicone  
- Disodium phosphate dodecahydrate  
- Potassium chloride  
- Potassium dihydrogen phosphate  
- Sodium chloride  
- Water for injection

Piglets: 
- For the passive protection of newborn piglets through the active immunization of breeding sows and gilts, aimed at reducing mortality and clinical signs of neonatal enterotoxemia, such as diarrhea caused by enterotoxigenic Escherichia coli expressing adhesins F4ab (K88ab), F4ac (K88ac), F5 (K99), or F6 (987P). The persistence of these antibodies has not been established.  

- For the passive immunization of newborn piglets against necrotic enteritis through the active immunization of breeding sows and gilts, to induce neutralizing serum antibodies against the β-toxin of Clostridium perfringens type C.  
The persistence of these antibodies has not been established.  

Sows and gilts:  
- For the active immunization of breeding sows and gilts, aimed at inducing neutralizing serum antibodies against the α-toxin of Clostridium novyi type B. The relevance of neutralizing serum antibodies has not been experimentally established.  
- Antibodies were detected 3 weeks after completion of the basic vaccination schedule. The persistence of these antibodies has not been established.

Intramuscular use:  
- Dose: 2 ml/animal.  

Basic vaccination schedule:  
- Consists of the administration of two doses:  
  - First dose: approximately 6 weeks before farrowing.  
  - Second dose: approximately 3 weeks before farrowing.  
- It is recommended to administer the second dose, preferably, on alternate sides of the neck.  

Revaccination:  
- For each subsequent gestation, administer one dose 3 weeks before the expected farrowing date.  

For correct mixing with Suiseng Diff/A and Suiseng Coli/C:  
- The entire contents of the Suiseng Coli/C vaccine must be transferred into the free space of the Suiseng Diff/A bottle (50 ml bottle with 10 doses, 100 ml bottle with 25 doses, or 250 ml bottle with 50 doses).  
- A pre-sterilized transfer needle can be used, following these instructions:  
  - Remove the cap from the bottle containing the Suiseng Coli/C vaccine.  
  - Connect one end of the transfer needle to the Suiseng Coli/C bottle.  
  - Remove the cap from the bottle with free space containing the Suiseng Diff/A vaccine.  
  - Connect the opposite end of the transfer needle to the Suiseng Diff/A bottle.  
  - Transfer the entire contents of the Suiseng Coli/C vaccine into the Suiseng Diff/A bottle.  
  - After completion, separate the bottles and discard the transfer needle.  
  - Shake well before use. Administer a single dose of 4 ml of the mixed vaccines.  
It is recommended to administer the vaccine at a temperature between +15 °C and +25 °C.  
Shake before use.

Zero days.

Shelf life: 2 years.  
Shelf life after first opening of the primary packaging: 10 hours.  
Shelf life after mixing with Suiseng Diff/A: 10 hours.

Do not use after the expiry date indicated on the packaging.