Innovax ND IBD

Chicks.

Innovax-ND-IBD – concentrate and solvent for injectable suspension for chicks.

Each dose of the reconstituted vaccine (0.2 ml for subcutaneous use or 0.05 ml for in ovo use) contains: Recombinant turkey herpesvirus associated with the HVP360 strain, expressing the fusion protein of the Newcastle disease virus and the VP2 protein of the infectious bursal disease virus: ≥10³.³ PFU per dose.

Subcutaneous and in ovo use. Vaccine preparation: Standard aseptic precautions must be applied in all preparation and administration procedures. Liquid nitrogen handling must be performed in a well-ventilated area.

Use the solvent for cell-associated bird vaccines for reconstitution. For subcutaneous use, the vaccine is reconstituted according to the table below:

When this product is mixed with Nobilis Rismavac, both must be diluted in the same solvent bag and in the same manner: 400 ml of solvent for every 2,000 doses of both products or 800 ml of solvent for every 4,000 doses of both products.

For in ovo use, the vaccine is reconstituted according to the table below.

The solvent should be clear, red in color, without sediment, and at room temperature (15–25°C) at the time of mixing.

The preparation of the vaccine should be planned before removing vials from liquid nitrogen, calculating the exact number of vials and the necessary amount of diluent. There is no information regarding the number of doses per vial after removal from the container, so mixing vials with different numbers of doses and using incorrect diluent should be avoided.

Before removing vials from the container with liquid nitrogen, it is mandatory to wear gloves, long sleeves, a facial mask, and protective glasses. When removing vials from the container, keep your gloved hand as far from your face and body as possible.

When extracting a rack with vials from the liquid nitrogen container, only expose the vials that will be used immediately. It is recommended to handle a maximum of 5 vials (from one rack) at a time. Vials that will not be used immediately should be placed back into the liquid nitrogen container.

Defrost the vial content quickly by immersing it in clean water at 25–27°C and gently agitating the vials for content dispersion. To protect cells, after defrosting, the suspension should be immediately mixed with the diluent.

Dry the vial, break it at the neck level, and proceed as follows:
- Extract the vial content into a sterile syringe equipped with an 18-gauge needle.
- Insert the needle through the rubber stopper of the solvent bag and slowly add the syringe content into the solvent.
- Gently shake the bag, inverting it to mix the vaccine.
- Draw a small amount of solvent into the syringe to wash the vial, then inject the washing liquid back into the solvent bag.
- Remove the syringe and gently invert the bag 6-8 times for thorough vaccine homogenization.

The vaccine is now ready for use. After adding the vial content to the solvent, the ready-to-use product is a clear, red-colored injectable suspension.

Dosage: Subcutaneously: One injection of 0.2 ml per chick. In ovo: One injection of 0.05 ml per embryonated egg.

Administration: The vaccine is administered through subcutaneous injection in the neck region or through in ovo injection. The vaccine bag should be gently and frequently agitated during vaccination to ensure the homogeneity of the vaccine suspension and the correct administration of the viral titer, especially during long vaccination sessions.

Proper storage control: For correct storage and transport verification, vials should be positioned with the cap facing down in containers with liquid nitrogen. If the frozen suspension is at the top of the vial, it indicates that the suspension has thawed and should not be used.

Zero days.

Cellular concentrate: A 2 ml glass vial containing 2000 or 4000 doses. The vials are stored on a rack, and a colored clamp is attached to the rack to indicate the dosage: a salmon pink clamp for 2000 doses and a yellow clamp for 4000 doses.

Solvent: 400 ml polyethylene or multilayer plastic bags.
800 ml polyethylene or multilayer plastic bags.

*Not all packaging sizes may be available for sale.

Cellular concentrate:
It is stored and transported in liquid nitrogen (below -140 °C).

Solvent:
Store at temperatures below 25 °C.

Container:
Store the liquid nitrogen container in a vertical position, in a clean, dry, and well-ventilated room, separate from the hatching/sorting room in the hatchery.

The shelf life of the cellular suspension, as packaged for sale, is 3 years.
The shelf life of the solvent (polyethylene bags), as packaged for sale, is 3 years.
The shelf life of the solvent (multilayer plastic bags), as packaged for sale, is 3 years.
The shelf life after reconstitution according to the instructions is 2 hours.

Do not use after the expiry date indicated on the packaging.